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Hormones / Endocrine

Zinc: Function and Deficiencies

Zinc (Zn) is a micronutrient and essential cofactor/metal in many enzymes to include alkaline phosphatase, carbonic dehydratase, and polymerases and is obligatory for cell division and DNA synthesis (Crook, 2011). Deficiencies in Zn can cause several maladies such as increased risk of infections, infertility, impaired brain development, dermatitis, alopecia, low testosterone, and impaired smell/taste (Crook,…

Processed Foods, Cardiovascular Disease, and Insulin Resistance

Excessive consumption of processed foods is a dominant trend in North America in which 70% of calories are derived from refined carbohydrates to include alcohol, vegetable oils, and sugar (Ilich, Kelly, Kim, & Spicer, 2014). Such refined sources (i.e., sugar sweetened beverages) have become linked to pathological conditions like cardiovascular disease (CVD) and insulin resistance/type 2…

Obesity, Atherosclerosis, and Phospholipase Enzyme 2 (PLA2)

Phospholipase enzyme 2 (PLA2) represents a group of enzymes found in the plasma. In particular, the primary enzymes behind phospholipid hydrolyzing processes is found amongst a sub-group known as secretory PLA2 (SPLA2) and have been associated with atherosclerosis (Garces et al., 2010). As such, the following will explore said enzymes in greater detail, other biomarkers…

B5, Low Grade Chronic Inflammation, and Disease

Low grade chronic inflammation (LGCI) is a condition characterized by a persistent presence of inflammatory processes, that eventually manifests as tissue damage (Nasef, Mehta, & Ferguson, 2017). LGCI is also implicated with several diseases to include autoimmune disease, cardiovascular disease, stroke, and diabetes (Kenney, Wilmore, & Costill, 2012; Nasef et al., 2017). Essentially, mitigating the inflammatory…

Determining Optimal Vitamin D Levels

Optimal vitamin D levels, as measured by 25-hydroxyvitamin D, remains to be somewhat equivocal, thereby affecting recommended oral doses of vitamin D3. Since research indicates the critical relationship of vitamin D to optimal health, it behooves one to consider the nuances and implications of recommending supplemental vitamin D to individuals. The following will explore the…

Vitamin D3 Production

Vitamin D3, also known as cholecalciferol, is the precursor/pre-vitamin to 1,25-(OH)2D; the active form within the body, known as calcitriol (Chaplin & Jablonski, 2013). Vitamin D3 can be derived from sun exposure as well as foods such as fatty fish (i.e., salmon and sardines), plants (i.e., shitake mushrooms), fortified foods (i.e., milk, yogurt, butter, cheese)…

Vitamin E and Oxidation

Vitamin E is a fat-soluble compound along with A, D, and K. Said vitamin is most widely recognized by its anti-oxidant capabilities and capacity to maintain and protect cell membranes and lipoproteins (Gropper, Smith, & Carr, 2018). As a means of appreciating vitamin E’s role as an anti-oxidant, the following will briefly consider its structure,…

Hemochromatosis, Supplementation, and a Tale of Caution

Micronutrient supplementation falls within an industry that generates substantial sums of revenue; Dagerman (2012) noted that in 2009, the aforementioned industry generated 26.7 billion dollars with 1,000 new supplements entering the consumer market yearly, and more than 29,000 supplements available for purchase in total. With such an array of choices, and a lack of quality…

Vitamin D: Types, Utility, Screening, and Optimal Dosing

Vitamin D is a micronutrient that has been associated with significantly reducing all-cause mortality, and has been implicated in many diseases of modern civilization (Cannell, 2008). Furthermore, and most relevantly, vitamin D interacts with more that 200 genes and multiple organs, indicating its broad reach and influence upon human physiology (Cannell & Hollis, 2008; Wang,…

Metabolic Syndrome, Low-Density Lipoproteins, and Fish Oil

Metabolic syndrome (MS) is a condition defined by a constellation of associated risk factors that increase a person’s chances of contracting stroke, cardiovascular disease (CVD), and diabetes (Chen, Yen, Huang, Lee, Hsia, & Lin, 2012). Said risk factors include: abdominal obesity (waist circumference 102 cm for males, 88cm for females), impaired fasting glucose (≥6.1 mmol/L),…